Volume 58 Supplement 2 December 2001


Contents
Cereal foods, fibres and the prevention of cancers
Graeme H. McIntosh
Foreword
About the author
Abstract
Introduction
Dietary fibre and relevant phytochemicals
Cereal foods and protection against certain cancers
Colon cancer
Descriptive studies
Case-control studies
Cohort studies
Intervention studies
Intervention studies not supporting the hypothesis
Gastric cancer
Breast cancer
Prostate cancer
Mechanisms whereby foods rich in cereal dietary fibre might protect against colon cancer
Animal studies
Dietary fibre
Resistant starch
Non-nutrient phytochemicals with anticancer effects
Phytate
Phenolics
Lignans
Phytosterols
Wholegrain influences on other diseases
Summary
Recommendations
Acknowledgments
References
Tables
Table 1. A comparison of the dietary fibre content of wholemeal rye bread and white wheat bread
Table 2. Case-control studies for cereals and fibre intakes on colorectal cancer or adenoma risk
Table 3. Influence of diet and lifestyle factors on colon cancer risk in middle and western USA
Table 4. Faecal water markers of colon cancer risk in people fed resistant starch from high amylose maize, oat bran and low amylose starch foods
Table 5. Urinary excretion of lignans and isoflavones in breast cancer cases and controls and risk (expressed as OR) for quartiles of metabolic excretion and significance of the trend
Table 6. The influence of wholegrain consumption on relative risk of coronary heart disease deaths in women in the Iowa Women’s Health Cohort Study
Figures
Figure 1. The incidence of cancer cases in Australia diagnosed in 1996
Figure 2. The close association of lignans with dietary fibre in milling fractions of rye
Figure 3. Odds ratio (log) for wholegrain consumption in gastric cancer case-control studies
Figure 4. A well accepted model of the pathogenesis of colon cancer
Figure 5. Influence of daily stool weights on colon cancer incidence in 23 populations
Figure 6. Conversion of plant lignans to mammalian lignans by colonic microflora







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